Efficacy of Tranexamic Acid on Blood Loss in Normal Vaginal Delivery

Introduction: Postpartum hemorrhage (PPH) is a substantial cause of maternal death, particularly in underdeveloped countries. Identifying safe, user-friendly, and cost-effective regimens is critical for managing postpartum hemorrhage (PPH). People often use Tranexamic acid (TA), an antifibrinolytic drug, to prevent and treat hemorrhage. It should be evaluated to ensure that it meets these requirements. This study sought to determine the efficacy of tranexamic acid in reducing postpartum blood loss following normal vaginal birth. Materials and Methods: We randomly assigned 104 pregnant women with singleton term pregnancies intended for vaginal delivery to one of two groups: tranexamic acid (group A) or control (group B). We measured blood pressure, respiration rate, pulse rate, oxygen saturation, urine output (ml/hr), hemoglobin (gm), and PCV (%) before and after delivery. We collected data on the need for additional uterotonics and the length of hospital stay. Results: The mean blood loss from delivery to 30 minutes post-delivery was 92.15 ml in group A and 178.9 ml in group B. The volume of blood loss decreased significantly from 30 minutes to 120 minutes post-delivery, measuring 25.78 ml in group A and 54.92 ml in group B. Yang H et al. (22.3%). Group A had considerably higher mean levels of SBP, DBP, pulse rate, respiratory rate, and SpO2 than group B. Conclusion: Tranexamic acid, when administered prophylactically as an antifibrinolytic medication, appears to diminish blood loss during normal labor, reduce the necessity for extra uterotonics, shorten hospital stays, and effectively lower the risk of postpartum haemorrhage.