COVID-19 long-term consequences: rapidly progressing cor pulmonale and its relation to hypercoagulation

Patients with COVID-19 exhibit alterations in the coagulation process and are associated with respiratory and cardiovascular diseases, including acute respiratory distress syndrome and acute cor pulmonale. we described the effects of systemic thrombolysis on acute cor pulmonale in a patient suffering from COVID-19 long-term consequences. We examined the correlation between the Rapidly progressing cor pulmonale and its relation to hypercoagulation in 45 post COVID-19 patients at Osh State University, utilizing laboratory characteristics, radiological studies, and other clinical markers. A negative moderate correlation between PTI% and PT sec, suggesting that as PTI% decreases, the PT sec increases, potentially signalling hypercoagulability and the correlation between these variables is statistically significant (p<0.05). Moreover, a positive moderate correlation between PTI% and fibrinogen, indicating that lower PTI% is associated with higher fibrinogen levels. This correlation was also statistically significant (p<0.05). The study underscores the multifaceted nature of long-term COVID-19 complications, emphasizing the need for comprehensive patient monitoring. The significant correlations involving PTI% could serve as valuable indicators for clinicians to assess the risk of hypercoagulation and inflammation in patients, potentially guiding more tailored and timely interventions. However, the predominance of insignificant correlations calls for cautious interpretation of the results. It suggests that while some relationships between these physiological parameters and long-term COVID-19 complications exist, they may not be straightforward or may be influenced by other factors not captured in this analysis. This highlights the importance of holistic patient assessment and the potential for individual variability in response to long-term COVID-19.