Synthesis, Spectroscopic Elucidation, Density Functional Theory (DFT) Calculations, Toxicological Effects and Biological aspects of Novel Heterobimetallic Cu(II) complexes containing 2,6-diaminopyridine Moiety

Abstract: A novel series of heterobimetallic complexes of copper has been synthesized possessing 2,6-diaminopyridine moiety. All the synthesized complexes have been characterized in the light of various physicochemical techniques like elemental analyses, conductance measurements, molecular weight determination, electronic, infrared and electronic spin resonance X-ray, mass spectral studies and DFT analysis. The observed low conductance values of the synthesized heterobimetallic complexes suggest their non-ionic character. The studies presented in the series unveils the propensity of Cu(II) complexes with general formula [Cu(C5H5N3)2M'2(R)4Cl2] where M'=Sn, Si, Ti or Zr and R= CH3,C6H5 or C5H5 against microbial pathogens Fusarium oxysporum, Rhizopus nigricans, Escherichia coli and Bacillus subtilis. Amid all the heterobimetallic complexes, the one presenting most promising antimicrobial activity was assessed on male albino rats for its toxicological effect by comparing the results with the standard fungicide Bavistin. Keywords: Bimetallic complexes, Heterobimetallic complexes, DFT investigation, Antibacterial activity, Antifungal activity, Toxicological. Title: Synthesis, Spectroscopic Elucidation, Density Functional Theory (DFT) Calculations, Toxicological Effects and Biological aspects of Novel Heterobimetallic Cu(II) complexes containing 2,6-diaminopyridine Moiety Author: Madhu, P. Sharma, A. Singh, Ashu Chaudhary International Journal of Recent Research in Physics and Chemical Sciences (IJRRPCS) ISSN 2350-1030 Vol. 12, Issue 1, April 2025 - September 2025 Page No: 17-28 Paper Publications Website: www.paperpublications.org Published Date: 07-June-2025 DOI: https://doi.org/10.5281/zenodo.15614188 Paper Download Link (Source) https://www.paperpublications.org/upload/book/Synthesis,%20Spectroscopic%20Elucidation,%20Density%20Functional%20Theory%20(DFT)-07062025-1.pdf