Pharmaceutical and Agricultural Significance of Trichoderma harzianum Metabolites

Abstract- Currently, diseases are mainly managed by chemical pesticides. The use of these chemical pesticides causes environmental problems because they do not undergo biodegradation or degrade very slowly. Therefore, minimizing the use of pesticides has gained importance. To achieve this goal, biological control methods can be effectively combined with other disease control methods. Trichoderma sp. Soil-borne filamentous fungi are effective biocontrol agents against plant pathogens. The present investigation isolated antagonistic organisms and determined the antifungal activity of the antagonistic organisms in HPLC fractions of the mycelial extract. The antifungal activity of HPLC fractions of the mycelial extract were collected in separate vials; thereby, these HPLC fractions of the mycelial extract were analyzed by FT-IR, and many antibiotic compounds were identified. The FT-IR results were then confirmed by GC-MS.