FEATURES OF THE IMMUNE RESPONSE IN LONG-TERM NON-HEALING WOUNDS: PREDICTION AND PREVENTION OF COMPLICATIONS

The study is devoted to the peculiarities of the immune response in long-term non-healing wounds and methods for predicting and preventing infectious complications. Changes in cellular and humoral immunity were studied in 120 patients with chronic wounds. Assessment of inflammatory markers, blood cell composition, and cytokine activity showed significant impairment of immune activity, which increases the risk of generalization of infection. The study used a combination therapy with immunomodulators and antibacterial drugs. The results obtained allow us to develop effective methods for preventing infectious complications and improving the prognosis of healing.