RELEASE KINETIC STUDIES OF FORMULATED ROXATIDINE ACETATE FLOATING TABLETS

ABSTRACT The objective of this study was to formulate and evaluate floating tablets of Roxatidine acetate, aiming to prolong gastric retention and ensure controlled drug release. Floating tablets were prepared using three different hydrophilic polymers HPMC K15M, Eduragit L 100, and Carbopol 934 as release- retarding polymers and effervescent agent, sodium bicarbonate to achieve buoyancy. Nine different formulations were prepared. The in vitro release studies were conducted in 0.1 N hydrochloric acid at 37°C using USP dissolution apparatus II. The release profiles were analyzed for their release kinetics, including zero-order, first-order, Higuchi, and Korsmeyer-Peppas models. The floating behavior of the tablets was evaluated by measuring floating lag time and total floating time. The release kinetics followed a near-zero-order or anomalous diffusion pattern, indicating a controlled release mechanism, and the tablets exhibited excellent buoyancy, remaining a float for up to 12 hours. The kinetic model provided the best fit for the release data, with an exponent (n) suggesting a non-Fickian diffusion mechanism. The formulated floating Roxatidine acetate tablets showed promise for sustained drug release, offering potential advantages for the treatment of gastric conditions like peptic ulcers and GERD by improving bioavailability and reducing dosing frequency.