DETECTION OF MACROPHAGE POLARIZATION IN GESTATIONAL PYELONEPHRITIS USING CD68 AND CD163 MARKERS

Gestational pyelonephritis is one of the most common nephrological complications during pregnancy, significantly affecting the general condition of the pregnant woman and the development of the fetus. Inflammation plays a central role in the pathogenesis of this disease, and its systemic analysis is crucial for understanding the specific immune responses associated with pregnancy. Macrophages are among the main effector cells in inflammatory processes and can polarize into M1 (pro-inflammatory) and M2 (anti-inflammatory) phenotypes. Detection of macrophage polarization using immunohistochemical markers such as CD68 and CD163 provides deeper insight into the pathogenesis of gestational pyelonephritis.