STUDY OF INTRA-INDIVIDUAL VARIABILITY OF PHARMACOKINETIC PARAMETERS OF IPIDACRINE

The pharmacokinetics and bioavailability of various ipidacrine drugs were studied, and the pharmacokinetics of Neuromidin® tablets 20 mg (JSC Olainfarm, Latvia) was studied. The study determined the concentration of ipidacrine in volunteers' blood plasma samples before and after administration. The duration of the blood sampling period of 24 hours (~4xT1/2) was sufficient for AUC0-t to overlap at least 80% of AUC0-∞. 656 blood samples were obtained from 41 volunteers over two study periods. Individual pharmacokinetic parameters were calculated for each volunteer: Cmax, Tmax, AUC0-t, Cmax/ AUC0-t, MRT0-t, kel, T1/2, AUC0-∞, AUC0-t / AUC0-∞, f’, f”. It has been established that ipidacrine is characterized by low (< 26%) intra-individual variability of pharmacokinetic parameters.