THE EFFECTIVENESS OF MULTI-COMPONENT ANTI-TUBERCULOSIS DRUGS IN THE TREATMENT OF PULMONARY TUBERCULOSIS

<p><em><span>In order to study the effectiveness of multicomponent fixed-dose anti-tuberculosis drugs in the treatment of pulmonary tuberculosis, we examined 22 patients with infiltrative pulmonary tuberculosis, while the control group consisted of 25 patients with infiltrative pulmonary tuberculosis. A multicomponent anti-tuberculosis drug consisting of isoniazid, rifampicin, pyrazinamide, and ethambutol was prescribed to patients in phase 1. Patients in the control group received rifampicin + isoniazid + ethambutol + pyrazinamide separately for 2-3 months. At the outpatient stage, the main group received a multicomponent drug containing R450H300 for a period of 4 months, whereas the control group took these drugs separately. </span></em></p> <p><em><span>Dynamic observations showed that in the main group, the indicators of the decrease in clinical symptoms of intoxication and respiratory manifestations, decrease in MBT release, and positive radiological dynamics did not differ from the control group of patients who received the drugs separately. </span></em></p>

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-03-05
DOI
https://doi.org/10.5281/zenodo.14969892
Primary Topic
Tuberculosis Research and Epidemiology
Type
article
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article

THE EFFECTIVENESS OF MULTI-COMPONENT ANTI-TUBERCULOSIS DRUGS IN THE TREATMENT OF PULMONARY TUBERCULOSIS

Zenodo (CERN European Organization for Nuclear Research)
Tuberculosis Research and Epidemiology
article

THE EFFECTIVENESS OF MULTI-COMPONENT ANTI-TUBERCULOSIS DRUGS IN THE TREATMENT OF PULMONARY TUBERCULOSIS

article en

Abstract

<p><em><span>In order to study the effectiveness of multicomponent fixed-dose anti-tuberculosis drugs in the treatment of pulmonary tuberculosis, we examined 22 patients with infiltrative pulmonary tuberculosis, while the control group consisted of 25 patients with infiltrative pulmonary tuberculosis. A multicomponent anti-tuberculosis drug consisting of isoniazid, rifampicin, pyrazinamide, and ethambutol was prescribed to patients in phase 1. Patients in the control group received rifampicin + isoniazid + ethambutol + pyrazinamide separately for 2-3 months. At the outpatient stage, the main group received a multicomponent drug containing R450H300 for a period of 4 months, whereas the control group took these drugs separately. </span></em></p> <p><em><span>Dynamic observations showed that in the main group, the indicators of the decrease in clinical symptoms of intoxication and respiratory manifestations, decrease in MBT release, and positive radiological dynamics did not differ from the control group of patients who received the drugs separately. </span></em></p>

Zenodo (CERN European Organization for Nuclear Research)
Good health and well-being
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Tuberculosis Research and Epidemiology
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