Formulation and Evaluation of Betel Leaves (Piper Betel L.) and Jackfruit (Artocarpus Heterophyllus Lam.) Extract as Antiacne Cream

The present study aimed to develop and evaluate a herbal anti-acne cream formulated with Piper betel (betel leaves) and Artocarpus heterophyllus (jackfruit seeds) extracts, along with Aloe vera, glycerine, lavender oil, and other excipients. Acne vulgaris, a common inflammatory skin condition, is often aggravated by bacterial activity, excess sebum production, and hormonal factors. Herbal ingredients offer antimicrobial and anti-inflammatory properties with minimal side effects. The prepared formulations (F1, F2, F3) were evaluated for physicochemical properties, irritancy, spreadability, FTIR characterization, and antimicrobial activity. Results confirmed that the cream was stable, non-irritating, and effective against acne-causing bacteria (Staphylococcus aureus, Propionibacterium acnes, and Staphylococcus epidermidis). The formulation shows potential as a natural, safe, and effective alternative to conventional anti-acne treatments.