Pharmacogenetics of intravenous fentanyl for postoperative analgesia in south Indian population

Fentanyl, a potent synthetic opioid, is widely used for postoperative pain management. However, significant interindividual variability in analgesic response and adverse effects limits its clinical utility. Pharmacogenetics offers insights into genetic factors influencing fentanyl pharmacokinetics and pharmacodynamics. This study aims to explore the impact of genetic polymorphisms on fentanyl efficacy and safety in the South Indian population. Single nucleotide polymorphisms (SNPs) in genes such as OPRM1, CYP3A4, and ABCB1 were analyzed. The findings highlight the importance of personalized approaches to postoperative pain management