DEVELOPMENT AND EVALUATION OF TRANSDERMAL PATCH CONTAINING COLCHICINE

The present research work was intended to prepare transdermal patch containing Colchicine as a model drug. Matrix type of colchicine containing transdermal patch was prepared by solvent casting method using three rate controlling polymers like HPMCK4M, ethyl cellulose and PVPK30. Fixed concentration (2%) of all three polymers was utilized for the preparation of patch. Compatibility study of drug with the excipients was determined by I.R. Spectroscopy, Thickness of the patch was measured by using screw gauge. The thickness of prepared patch was found in the range of 0.310 to 0.315 mm. Batch F3 showed highest thickness of patch. The weight of the prepared transdermal patches for different formulations ranged between 52.14±1.20 to 55.70±1.98 mg. The percentage of drug content of formulation batch F1 to F7 varied between 94.04±1.23 to 97.26±0.31%.The folding endurance value for all batch formulations was found within range of 64 to 87. Patches formulated with ethyl cellulose (F2) showed the patch formulation F1, F2 and F3, formulated with HPMC, ethyl cellulose, and PVP K30, without addition of permeation enhancer in fixed concentration i.e. 2%, showed drug release of 72.16±0.33, 61.12±1.40 and 66.53±0.62% at the end of 24 hrs respectively. The developed optimized matrix type transdermal patch formulation was found to be stable during the stability study for the period of 3 month indicating good stability of the product.