Formulation and Evaluation of Transdermal Patches of Meloxicam by Solvent Casting Method

The objective of this study was to formulate and evaluate meloxicam transdermal patches using Hydroxypropyl Cellulose (HPC) as the sole polymer, aiming to provide a controlled release system for effective pain management. Because meloxicam, a non-steroidal anti-inflammatory drug (NSAID), causes gastrointestinal side effects and has low oral bioavailability, transdermal delivery is an ideal alternative. To improve flexibility propylene glycol was used as a plasticizer in the formulation. Drug content, moisture content, moisture uptake, folding endurance, flatness, thickness, weight variation, and in vitro drug release studies were tested. Due to the hydrophilic nature of HPC, findings indicated that patches based on HPC contained more moisture content and moisture uptake, which increased drug release and flexibility of the film. Controlled and sustained release of meloxicam was proven through the in vitro release tests, suggesting the potential for longer-lasting therapeutic effects with fewer side effects. The research revealed that transdermal patches with HPC have showed sufficient stability and bioavailability.