ECOFRIENDLY SPECTROSCOPIC METHOD DEVELOPMENT FOR SIMULTANEOUS ESTIMATION OF ANTIHYPERTENSIVE DRUGS IN COMBINED DOSAGE FORM

The present study focuses on the development of an ecofriendly spectroscopic method for the simultaneous estimation of antihypertensive drugs in a combined dosage form. The method was designed to be simple, cost-effective, and environmentally sustainable by avoiding the use of hazardous organic solvents and minimizing chemical waste. Using UV-visible spectroscopy, optimized wavelengths were selected for accurate quantification of the drugs without interference from excipients. The proposed method was validated as per International Conference on Harmonisation (ICH) guidelines for parameters such as linearity, accuracy, precision, specificity, limit of detection (LOD), and limit of quantitation (LOQ). Recovery studies at three concentration levels (80%, 100%, and 120%) confirmed the method’s accuracy, with percentage recovery values within the acceptable range for both drugs. The ecofriendly nature of the method not only ensures environmental safety but also offers a sustainable alternative for routine quality control analysis in the pharmaceutical industry. Keywords: Ecofriendly method, UV-visible spectroscopy, simultaneous estimation, antihypertensive drugs, green analytical chemistry, method validation, recovery studies, sustainable analysis.