Berberine And Its Study as An Antidiabetic Compound

A metabolic disease called diabetes mellitus (DM) results in hyperglycemia and a number of chronic consequences that can be fatal. The high toxicity levels of existing diabetic medications and the expected further rise in diabetes prevalence have led to extensive research into natural substances, such as berberine, as potential alternative diabetes treatments. Berberine and several other alkaloid compounds, including some of its derivatives, have shown many bioactivities, such as neuraminidase and hepatoprotective activity. properties. By activating the AMPK system, berberine, an antidiabetic substance, is known to lower blood glucose levels, boost insulin production, and impair insulin resistance and glucose tolerance. Apart from being an antidiabetic compound, berberine also exhibits various other activities such as being anti-adipogenic, anti-hyperlipidemic, anti-inflammatory, and antioxidant. Many studies have been conducted on berberine, but its exact mechanism still needs to be clarified and requires further investigation. As a naturally occurring substance with a variety of uses, mostly as an antidiabetic, berberine and its mechanism will be covered in this review[1]. A metabolic condition with a high death and morbidity rate is type 2 diabetes (T2D). Non-coding RNAs, which include both long and small non-coding RNAs, are a new class of functional RNA molecules that control a variety of biological processes [2].