TRANSCRIPTOMIC LANDSCAPE OF MENINGIOMAS: ANALYSING GENE EXPRESSION PROFILES ACROSS DIFFERENT ANATOMICAL LOCATIONS.

Meningiomas are the most common adult brain tumors and are approximately 30% of all intracranial neoplasms (1). Multiple studies show that skull base meningiomas (SBM) are more likely to have benign biology whereas tumors with more aggressive behavior can constitute close to 30% of convexity/parafalcine tumor (2). Significant difference in immune-cell gene expression was seen between SBM and convexity meningiomas by Zador Z et al. which explained the biology of the aggressive nature of Non-skull basemeningiomas (NSBM) (3). The gene expression profiles between different anatomical subtypes i.e Skull Base Meningiomas versus Non-skull base meningiomas, remain largely unexplored.