CLINICO-MICROBIOLOGICAL PROFILE OF CENTRAL LINE ASSOCIATED BLOOD STREAM INFECTION (CLABSI) AND ASSOCIATED RISK FACTORS AMONG PATIENTS ADMITTED IN A TERTIARY CARE HOSPITAL, NAVIMUMBAI

Background – Central line-associated bloodstream infection is an infection thatoccurs when microorganisms enter bloodstream through central line that occurswithin 48 hours of central line placement. This study undertaken to determineclinico-microbiological profile, antimicrobial susceptibility pattern and riskfactors associated with CLABSI.Methods – This is a descriptive and Prospective Study from January toDecember 2022, under aseptic conditions 30 IPD patients' blood were culturedmanually and a catheter tip culture were cultured using the semi-quantitativeroll-plate and quantitative vortex method. Kirby-Bauer disk diffusion methodused to study Antibiotic susceptibility profiles. All the results were statisticallyanalysed by using Crude Odds Ratio and P value.Result- out of 30 samples, 18 (60%) were CLABSI positive. The majority ofCLABSI patients were in ICU (83%) and highly prevalent over the age of 50(61%) and in men (66%).CLABSI rate in our study period was determined tobe 2.73 (1.58 - 4.50) per 1000 catheter days. Gram Negative Bacteria (61%)were found to be higher in prevalence than Gram Positive (39%) Bacteria, withEnterobacter (36%) being with greatest incidence among GNB and S. aureus(43%) among GPC. variant and Independent risk variables were alsoinvestigated.Conclusion- According to this study, high risk variables related with CLABSIwere identified, and more MDR organisms were isolated. To reduce this, it isessential to follow proper antibiotic policies, central line insertion andmaintenance bundles.