Synthesis of Schiff Base under Solvent-free Condition: As a Green Approach

Abstract This study explores an environmentally friendly approach for synthesizing Schiff bases, a class of compounds with diverse applications. Traditional methods often involve harmful solvents and catalysts, raising concerns about environmental impact. To address these issues, we developed a solvent-free microwave-assisted synthesis of salicylaldimine Schiff bases. This green approach involves directly irradiating salicylaldehyde with various substituted aryl amines, eliminating the need for any additional solvents or catalysts. The successful synthesis of these compounds was confirmed through elemental analysis and thin-layer chromatography (TLC). This solvent-free method offers several advantages, including increased product yield, enhanced purity, and reduced environmental impact. The findings of this study demonstrate a promising alternative for the efficient and sustainable synthesis of Schiff bases.