Formulation And Evaluation of Novel Herbal Antiaging Gel Cream Containing Rambutan Fruit

Skin aging is a multifaceted biological process influenced by internal and external factors, including UV exposure, pollution, and lifestyle choices. The demand for safe, natural anti-aging solutions has driven research toward herbal formulations. This study focuses on formulating and evaluating a novel herbal anti-aging gel-cream using rambutan fruit (Nephelium lappaceum) extracts. Rich in bioactive compounds like alkaloids, flavonoids, and tannins, rambutan demonstrates significant antioxidant and anti-inflammatory properties, making it a suitable candidate for skin care. The gel-cream was prepared with rambutan pulp and seed extracts, combined with ingredients such as beeswax, olive oil, almond oil, and aloe vera for hydration and stabilization. Six formulations (F1-F6) were developed, evaluated for physical, pharmaceutical, and stability parameters. Key tests included pH determination, viscosity, spreadability, and skin irritation, alongside phytochemical analysis for active components. Results indicated that formulations F2 and F6 showed optimal stability, homogeneity, spreadability, and non-greasy properties. No signs of irritation were observed during dermatological testing. The study concludes that the rambutan-based herbal gel-cream is a safe, effective anti-aging product with potential for cosmetic development.

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-02-12
DOI
https://doi.org/10.5281/zenodo.14854758
Primary Topic
Advancements in Transdermal Drug Delivery
Type
article
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article

Formulation And Evaluation of Novel Herbal Antiaging Gel Cream Containing Rambutan Fruit

Zenodo (CERN European Organization for Nuclear Research)
Advancements in Transdermal Drug Delivery
article

Formulation And Evaluation of Novel Herbal Antiaging Gel Cream Containing Rambutan Fruit

article en

Abstract

Skin aging is a multifaceted biological process influenced by internal and external factors, including UV exposure, pollution, and lifestyle choices. The demand for safe, natural anti-aging solutions has driven research toward herbal formulations. This study focuses on formulating and evaluating a novel herbal anti-aging gel-cream using rambutan fruit (Nephelium lappaceum) extracts. Rich in bioactive compounds like alkaloids, flavonoids, and tannins, rambutan demonstrates significant antioxidant and anti-inflammatory properties, making it a suitable candidate for skin care. The gel-cream was prepared with rambutan pulp and seed extracts, combined with ingredients such as beeswax, olive oil, almond oil, and aloe vera for hydration and stabilization. Six formulations (F1-F6) were developed, evaluated for physical, pharmaceutical, and stability parameters. Key tests included pH determination, viscosity, spreadability, and skin irritation, alongside phytochemical analysis for active components. Results indicated that formulations F2 and F6 showed optimal stability, homogeneity, spreadability, and non-greasy properties. No signs of irritation were observed during dermatological testing. The study concludes that the rambutan-based herbal gel-cream is a safe, effective anti-aging product with potential for cosmetic development.

Zenodo (CERN European Organization for Nuclear Research)
Openalex Percentile: Top 56%
Advancements in Transdermal Drug Delivery
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