Formulation And Evaluation of Carvedilol Melt‑In‑Mouth Tablet Using Mucoadhesive Polymer

The aim of this study was to develop and evaluate carvedilol melt-in-mouth tablets incorporating a mucoadhesive polymer to enhance bioavailability and improve patient compliance, particularly for those with difficulty swallowing tablets. Carvedilol is a non-selective β-blocker, primarily used in the management of hypertension and heart failure. This formulation approach is designed to provide rapid onset of action and ensure a controlled release of the drug at the site of action. The incorporation of mucoadhesive polymers helps to improve the retention time of the tablet in the oral cavity, enhancing absorption and therapeutic efficacy.