FEATURES OF THE USE OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS IN RHEUMATIC DISEASES.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used in the treatment of rheumatic diseases to control pain and inflammation. However, in the treatment of ankylosing spondylitis (AS), NSAIDs have not only a symptomatic effect, but also a structural-modifying effect, slowing the development of spinal ankylosis. The effect of these drugs may be related to the anti-inflammatory effects and the ability to inhibit pathologic bone proliferation underlying syndesmophyte formation. There is strong clinical evidence supporting the ability of NSAIDs to reduce the rate of radiologic progression of AS with long-term continuous use. Therefore, continuous use of NSAIDs should be considered a mandatory component of pharmacotherapy of this disease. Of this disease. The use of NSAIDs is reasonable to continue even after achieving marked clinical improvement. At the same time, in this situation, careful control of the development of side effects in the form of disorders of the structure and functions of the gastrointestinal tract and cardiovascular system is required. The danger of these complications necessitates the attention of the doctor, mandatory consideration of risk factors and rational choice of the safest NSAIDs. Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective means of controlling acute and chronic pain, widely used in the complex therapy of chronic rheumatic diseases. Such a judgment is generally justified with regard to the use of NSAIDs in RHs such as rheumatoid arthritis (RA) and osteoarthritis. However, there are RDs in which NSAIDs have not only a symptomatic but also a distinct pathogenetic effect.