Drug Interaction Study of Gastric Irritant Drugs (Nsaids, Iron Supplements and Antibiotics) And Drugs Used in The Treatment of Gastric Irritation Using Online Software

Background Drug-drug interactions result in unintended reactions, toxic side effects, or a lack of clinical efficacy in an individual body when multiple medications are simultaneously administered for one or more disease. Pharmacokinetic interactions concerning drug absorption, distribution, metabolism, and excretion (ADME cycle) variations may result in a plasma concentration fluctuation, influencing drug bioavailability. Pharmacodynamically, drugs can interact by binding to the same receptor. Aim and Objective Our study focuses on exploring the interaction profile of Gastric irritant drugs (NSAIDs, Iron supplements and Antibiotics) and drugs used in the treatment of Gastric irritation using online software (drugs.com). Result and Discussion Usually NSAIDs, Iron supplements and Antibiotics are concomitantly given with gastric acid suppressants (Antacids, Proton pump inhibitors, H2 blockers, Prokinetic agents) to tackle their gastric side effects. This study aided to determine the combinations of Iron supplements and Antibiotics and gastric acid suppressants that are free from drug interactions. Conclusion This would serve as a ready reference guide for medical practitioners, pharmacists and other health care professionals to choose combination of NSAIDs, Iron supplements and Antibiotics and gastric acid suppressants to treat or prevent their gastric side effects in a more efficient manner