A Review on analytical Methods for Hydrochlorothiazide and Losartan Potassium

Hydrochlorothiazide is a diuretic medication used to treat hypertension and swelling due to fluid build-up. Hydrochlorothiazide is a thiazide medication which inhibits reabsorption of sodium and chloride ions from the distal convoluted tubules of the kidneys, causing a natriuresis. This initially increases urine volume and lowers blood volume.Losartan is a medication used to treat high blood pressure (hypertension). It is in the angiotensin receptor blocker (ARB) family of medication, and is considered protective of the kidneys. Besides hypertension, it is also used in diabetes, kidney disease, heart failure, and left ventricular enlargement.Losartan potassium and hydrochlorothiazide is a combination of two medications that work together to lower blood pressure.Various analytical methods such as High-performance liquid chromatography (HPLC), High-performance thin layer chromatography (HPTLC), and UV-Spectrophotometric methods have been developed for the estimation of Hydrochlorothiazide single and combinations with Losartan Potassium have been reported.