Testing the Efficacy of Two Antibiotics, (Tetracycline and Amoxicillin) on Bacteria Isolated from the Intestine of Wild African Catfish (Clarias Gariepinus Burchell, 1822) from Ajiwa Reservoir, Katsina State, Nigeria

Antibiotics are powerful medicines that fight certain infections. However, illegal dumping of human andlivestock wastes into water bodies has severe consequences, including the development of antibioticresistant bacteria. This study isolated and identified bacteria from the intestine of wild Clarias gariepinus(African catfish) from the Ajiwa reservoir. Nine fish samples (W1-W9) yielded five different bacteriaspecies: Pseudomonas aeruginosa, Escherichia coli, Cytrobacter freundii, Acinetobacter baumannii, andKlebsiella pneumoniae. Antibiotic effectiveness was determined using Kirby-Bauer disc diffusion. Allisolated bacteria showed 100% effectiveness to Tetracycline, except one Pseudomonas spp (W3), whichshowed 13.5% effectiveness. However, all isolates were 100% resistant to Amoxicillin. These resultssuggest that Tetracycline has minimal interference, while Amoxicillin has abundant resistance. Theintroduction of multi-antibiotic-resistant bacteria from terrestrial environments poses a significant threatto aquatic ecosystems and human health.