In- vitro Pharmacological Evaluation of Flavonoid Rich Fractions of Betula Utilis and Annina Squamosa on Colon Cancer

The majority of colon cancers are one of the principal causes of cancer-related deaths all over the world. The search for good and safe medicinal therapy is just a recent interest; flavonoid-rich fractions from exclusive plants have received attention in connection with this goal. The present study revolves around pharmacological assessments in vitro of flavonoid-rich fractions derived from Betula and Annona squamosa for colon malignancies. The fractions were found to exert notable anti-inflammatory, antiproliferative, and apoptotic actions on colon cancer cells. These effects were mediated through the modulation of signaling pathways. Thus, this study supports the possible use of flavonoid-rich fractions of Betula utilis and Anonna squamosa as therapeutics for the majority of colon malignancies.