Formulation And Evaluation Of Floating Drug Delivery For The Treatment Of Ulcer And Antibiotic Caused By H.Pylori Infection

The objective of this study is to formulate a bilayer tablet consisting of an anti-ulcer and antibiotic combination, where the immediate release layer contains omeprazole and the sustained release layer contains tinidazole. In addition to formulation, the study aims to perform in vitro release testing on the bilayer tablet. The purpose of combining these drugs, which have complementary mechanisms of action, is to create a fixed dose, enhance patient adherence, optimize formulation for improved safety, and maximize the therapeutic effectiveness of the medications. Various approaches have been developed, such as floating drug delivery systems, swelling and expanding systems, bio-adhesive systems, modified release systems, and high-viscosity systems. Floating drug delivery systems are particularly relevant for locally acting medications with a short residence time in the stomach or upper small intestine, as they are unstable in the intestinal or colonic region and have low solubility at high pH. This review provides comprehensive insights into the pharmacological basis of their design, classification, advantages, and diverse aspects of the Floating drug delivery system, and also discusses the potential of floating drug delivery systems in the future.