An Association between Uric Acid and Hypothyroidism – A Retrospective Case Control Study

Background: Hypothyroidism affects kidney function to alter the level of uric acid in blood and hence has an impact on serum uric acid level. Method: The study included 50 known hyperuricemia cases and equal number of age and sex matched control. Serum uric acid, TSH, FT4, urea, creatinine data were collected from the record of patients who attended the department of Biochemistry, SCCGMCH, Uluberia. Result: Uric acid is positively associated with thyroid disease as Odds of exposure among cases are higher than control with Odds Ratio – 6. Statistically significant difference in UA, TSH, FT4 level was observed between case and control but there’s no significant difference observed in the urea and creatinine concentration although mean for urea and creatinine of case were slightly on higher side. Conclusion: Hypothyroid individual irrespective of treatment status is associated with increased Uric acid concentration