Compare the Effectiveness of Deflazacort and Prednisolone in Idiopathic Nephrotic Syndrome in Children

Background: Nephrotic syndrome is a manifestation of glomerular disease characterized by sever proteinuria, hypoalbuminemia and hyperlipidemia. It affects numerous children globally with idiopathic syndrome being the most common form in pediatric population. The therapeutic effectiveness and safety profiles of prednisolone and deflazacort in treating this condition necessitate further examination. Methodology: 100 patients were enrolled in this study between 1 to 10 years old who were diagnosed with idiopathic nephrotic syndrome. This study was conducted at BRD Medical College, Gorakhpur, for six months. Patients were randomly registered to receive either deflazacort of prednisolone. Results: Both treatments were effective in inducing remission with deflazacort, showing a slightly higher remission rate but no significant differences were found in growth parameters between the groups. Although, deflazacort was associated with some complications and adverse effects as compared to prednisolone. Both drugs significantly improved laboratory values such as ESR and protein/creatinine ratio with notable reductions in plasma urea and creatinine. Conclusion: Deflazacot may be considered as more favorable with efficacy and safety in the treatment of pediatric idiopathic nephrotic syndrome as compared to prednisolone.