A REVIEW ON METHOD DEVELOPMENT AND VALIDATION OF STABILITY INDICATING UV METHOD FOR CARVEDILOL

The present study describes the development of a new rapid, simple, sensitive and reproducible UV Spectrophotometry RP-HPLC, HPTLC method for the analysis of Carvedilol that offer certain advantages in its simplicity and sensitivity and applicable in routine analysis. It also describes the development of validation work as per ICH guidelines recommended by the Food and Drug Administration (FDA) of the United States. In order to develop a RP-HPLC, HPTLC, UV effective most of the effect should be spent in method development and optimization as this will improve the final method performance. A well- developed method should be easy to validate. A method should be developed with the goal to analyse rapidly, the preclinical samples, formulations and commercial samples. Review of literature on drug strongly indicates that there is few methods available for determination and validation of carvedilol in bulk and pharmaceutical dosage forms.