Complete Pathological Response in a Young Patient with Poorly Differentiated Gastric Adenocarcinoma Following Flot Neoadjuvant Chemotherapy: A Case Report

Gastric cancer remains a significant health issue, particularly when occurring in younger populations with more aggressive forms and poorer outcomes. Here, we present the case of a 24-year-old female diagnosed with poorly differentiated gastric adenocarcinoma. She presented with severe epigastric pain, progressive dysphagia, hyper salivation, melena, and significant weight loss. Diagnostic evaluations revealed a subcardial mass suggestive of Bormann type III gastric cancer. Following a multidisciplinary decision, neoadjuvant chemotherapy with the FLOT regimen was initiated, resulting in a 10% reduction in tumor size. The patient underwent spleen-preserving total gastrectomy with Roux-en-Y reconstruction and extensive lymph node dissection. Postoperative pathology showed no residual neoplasm or lymph node metastasis. This case highlights the importance of a multimodal approach, demonstrating the efficacy of the FLOT regimen in achieving a complete pathological response and underscores the potential for favorable outcomes even in rare and aggressive cases of gastric cancer.