Formulation Development of Paracetamol and Ibuprofen Suspension

The objective of this study was to develop a stable and effective suspension formulation of paracetamol and ibuprofen, and to compare its characteristics with marketed formulations. Five marketed formulations, namely Combiflam, Ibujesic Plus, Adiflam Plus, Aldigesic Plus, and Ibuflamar Plus, were evaluated for their physical, chemical, and microbiological properties. The results showed that the developed formulation had a pH of 5.5, viscosity of 1000 cps, and assay of 99.5% for paracetamol and 98.5% for ibuprofen. The suspension was stable for 6 months at 25°C/60% RH and 40°C/75% RH. The comparative study revealed that the developed formulation had similar characteristics to the marketed formulations, with some advantages in terms of stability and bioavailability.