Medicinal Mushrooms in Mental Health: A Review of TCM and Naturopathy

Medicinal mushrooms have long been an integral part of Traditional Chinese Medicine (TCM) and are increasingly recognized for their potential mental health benefits. This review examines the therapeutic properties of several medicinal mushrooms—Agaricus blazei, Coriolus versicolor, Ganoderma lucidum, Cordyceps sinensis, Hericium erinaceus, and Psilocybe cubensis—focusing on their bioactive compounds and applications in mental health. These mushrooms are rich in polysaccharides and triterpenoids, which contribute to their immunomodulatory, anti-inflammatory, and neuroprotective effects. Traditional uses and modern scientific findings suggest these mushrooms can reduce symptoms of anxiety, depression, and cognitive decline. While promising, most research has been preclinical, emphasizing the need for robust human clinical trials. Integrating the traditional knowledge of TCM with Naturopathy and scientific research could provide new, culturally acceptable, and effective treatments for mental health disorders. This review highlights the importance of expanding clinical trials to validate the therapeutic potential of medicinal mushrooms in mental health care.