Microwave Assisted One-Pot Multicomponent Synthesis of Amino Pyrazoles and its derivatives in Green Media

Abstract: A straightforward one-pot synthesis involving three components-5-amino-1,3-diphenyl-4,5-dihydro-1H-pyrazole-4-carbonitrile derivatives—was carried out under microwave radiation employing substituted aryl aldehyde, malononitrile, and phenyl hydrazine in catalytic amount of baker’s yeast in water as a high performance at room temperature. The recently created approach has faster reaction times, higher quantitative yields, simpler product isolation, green reaction conditions, and a straightforward workup process. Using TLC, Melting point and spectroscopic techniques such as, IR, 1HNMR, and Mass, the structure of the produced derivatives was verified