A Systematic Review in Pathogenesis, Epidemiology, and Therapeutic Advances of the Trypanosoma Diseases

This systematic review offers a comparative analysis of Trypanosoma-related diseases, focusing on African Trypanosomiasis (commonly known as sleeping sickness) caused by Trypanosoma brucei and Chagas disease caused by Trypanosoma cruzi. These illnesses represent major public health concerns in sub-Saharan Africa and Latin America, impacting millions of individuals. Although significant progress has been made in understanding the life cycles and host interactions of Trypanosoma species, their mechanisms of pathogenesis remain largely unclear. Additionally, current treatment options are limited and often associated with serious side effects. The review examines the epidemiology, clinical symptoms, and recent developments in therapeutic strategies for these diseases. Its findings aim to guide future research and clinical efforts, addressing knowledge gaps and enhancing treatment outcomes for affected communities.