Zinc-Enriched Steroid Receptors May Cause Alzheimer's

Abstract Decreasing steroid hormones, mostly estrogen, testosterone and vitamin-D - the latter predominantly associated with sparse sunlight - are accompanied by a reciprocal excess of their cytoplasmic type 1 receptors presumed to induce Alzheimer's Disease. Steroid receptors that escape binding to steroid hormones or other suitable ligands are not translocated to the cell-nucleus and may aggregate as unliganded zinc-enriched receptor-remnants in the cytoplasm, which by zinc-release promotes the formation of devastating neurofibrillary tangles. However, a part of these receptor-aggregates may become extruded via amyloid precursor protein (APP), contributing to Alzheimer's plaques outside the neurons. The evidence, as part of the research, is necessarily mathematical, which is, however, reasonably available.