Development And Evaluation Of Hydrolyzed Graft Copolymer Based Hydrogel Of Ornidazole For Treatment Of Periodontal Disease

Periodontitis is an inflammatory and plaque induced condition leading to the progressive and episodic loss of tooth attachment apparatus, for which intrapocket devices have gained the most preference. In this study, natural polysaccharide starch has been grafted with acrylamide monomer by microwave assisted grafting method using ammonium persulfate as a chemical initiator. Four sets of Ornidazole mucoadhesive gels (6% w/v) viz. F1, F2, F3 and F4 were prepared from hydrolyzed copolymers (GH1-GH4) respectively. The procedure and results for preparation of hydrolyzed graft copolymers and their evaluations are explained in reference 1. The gels were evaluated for pH, viscosity, thermal analysis, syringeability, spreadability, mucoadhesive strength, in vitro drug release and kinetic model application. All the formulations were found to be diffusion controlled and among all formulations, set F1 was proved to be most promising in terms of mucoadhesive strength (6.5±0.0553) and in-vitro diffusion (95.29% in 8 h) of drug.