Exploring 1, 4-Dihydropyridines: Synthesis, Biological Activities, Therapeutic Potentials and Computational Studies

Abstract: 1, 4-dihydropyridines and their derivatives are the foremost notable class of Nitrogen-containing heterocyclic scaffolds and have been extensively used since they are occupying the highest position in the pharmaceutical industry because of its wider range of biological and medicinal uses. One of the most straightforward and cost-effective techniques for creating biologically significant and pharmacologically beneficial 1,4-dihydropyridine derivatives is the conventional Hantzsch reaction, which was first described by Arthur Hantzsch. This review article will highlight the recent and green approach methodologies adopted to synthesize 1, 4-dihydropyridine derivatives with their anti-oxidant properties along with anti-bacterial activity, anti-fungal activity and computational studies. The study and distilled findings will be immensely instructive, valuable, and informative for researchers working in the domains of medicinal chemistry and drug development