THERAPEUTIC IMPLICATIONS OF THERMODYNAMICS SPECTROPHOTOMETRY IN HIV CONTROL DYNAMICS

Abstract: Due to continued HIV prevalence, control infectivity parameter was expressed and quantified through spectrophotometric data using historical absorbance data. The expression was incorporated in an adopted basic viral dynamics model, an Ordinary Differential Equation (ODE) and solved using the numerical integration that utilized explicit Runge-Kutta method in MATLABTM function ode 23 for the infection time course. The infection dynamics was allowed to progress from day zero to day nineteen without drug intervention while the drug intervention which basically was the introduction of the drug historical thermodynamic spectrophotometric absorbance data in the expressed model was introduced from day nineteen to day three hundred. The solution showed dynamics as expected in drug intervention. A clear change in the dynamics in day nineteen from progressive to regressive dynamics. A comprehensive control infectivity value of less than is an indication of curative ability of the expressed model for the two drugs D1 and D3 whose historical data were utilized. This signifies the existence of van der Waals force of repulsion between the two interacting particles. Higher than value for control infectivity parameter would have meant attraction. Again the infection time course from simulations validated the quantified result since the two dynamics of the infection time course represented the situation at both normal infection without treatment before day nineteen and at curative afterwards to day three hundred. Pharmaceutical industries should take note of this in drug design. Keywords: Human immunodeficiency virus, Absorbance, Interfacial energetics, Control Infectivity. Title: THERAPEUTIC IMPLICATIONS OF THERMODYNAMICS SPECTROPHOTOMETRY IN HIV CONTROL DYNAMICS Author: Dim, E. C., Ilo, C. P., Odo, L. A. International Journal of Recent Research in Interdisciplinary Sciences (IJRRIS) ISSN 2350-1049 Vol. 11, Issue 3, July 2024 - September 2024 Page No: 24-29 Paper Publications Website: www.paperpublications.org Published Date: 30-September-2024 DOI: https://doi.org/10.5281/zenodo.13860819 Paper Download Link (Source) https://www.paperpublications.org/upload/book/THERAPEUTIC%20IMPLICATIONS%20OF%20THERMODYNAMICS-30092024-1.pdf