Comprehensive Assessment of Mortality and Associated Co-Morbidities among Persons with Multiple Disabilities: A Systematic Review

Persons with multiple disabilities (PwMD) face high mortality and co-morbidity risks. Existing research has explored specific disability groups and individual co-morbidities, but a comprehensive synthesis is lacking. The primary objective of the review is to synthesize available evidence on mortality patterns and associated co-morbidities in PwMD and providing insight into health challenges and supporting the development of improved healthcare strategies. This Systematic review follows PRISMA guidelines. Two independent reviewers conducted the study selection, data extraction and quality assessment. Findings indicate that PwMD experience significantly higher mortality rates compared to the general population, particularly those with intellectual disabilities, cerebral palsy and autism spectrum disorder. Common co-morbidities include cardiovascular disease, respiratory disorders, and mental health issues such as depression and anxiety. Studies highlight the need for integrated healthcare approaches to address these physical and mental health challenges simultaneously.This Systematic review underscores the need for integrated, multidisciplinary healthcare strategies address the complex co-morbidities.