Timolol Eye drop, side effect in the form of Major Depressive Disorder with Psychotic Features

Abstract Investigating the drug side effect of timolol eye drops in glaucoma patients is not a new topic, but has been discussed for years, especially the psychological side effects of this drug on patients have been a proven issue. The case, which I am reporting, was a patient who had no psychological problems whatsoever until the age of 62, he had open-angle glaucoma after one year of starting treatment with timolol drops. But despite the fact that he had glaucoma surgery two years ago and his disease has improved to the point where he no longer takes any medication for glaucoma, the question is, why is the patient's depression not improving and I am still faced with ups and downs in his clinical condition, the patient is still being treated with antipsychotic drugs, and this question remains unanswered? Keywords: Glaucoma, Side Effects, Timolol, Psychological Problems.