ACETOLAZAMIDE USING IN IDIOPATHIC INTRACRANIAL HYPERTENSION

The management of patients with idiopathic intracranial hypertension (IIH) has been guided primarily by informed opinion, clinical experience, and a small number of primarily retrospective studies. Given the results of the IIH Treatment Trial (IIHTT), there is now evidence supporting the use of acetazolamide for patients with IIH, especially with visual loss. Acetazolamide, a compound developed in the 1950s as a diuretic drug and presently used as an antiglaucoma, antiepileptic and diuretic agent, is effective in the treatment of IIH. is a low nanomolar inhibitor of Carbonic anhydrase(CA) isoforms involved in cerebrospinal fluid (CSF) secretion. Inhibition of brain/choroid plexus CA II, IV, VA and XII leads to a decreased CSF fluid secretion and control of the intracranial pressure.