HbA1c Levels in PCOS-IR Rats (Rattus Norvegicus) Models After Administration of Moringa oleiferaExtract

Abstract: Polycystic Ovary Syndrome (PCOS) is a hormonal disorder characterized byirregular ovulation and the presence of small cysts on the ovaries. This condition isfrequently associated with obesity, insulin resistance, and diabetes. Aim: This researchaims to investigate the effects of Moringa oleifera leaves extract on HbA1c levels inwhite rats (Rattus norvegicus) that have been induced to model insulin-resistant PCOS.Moringa oleifera has various bioactive compounds such as flavonoids, that function asinsulin sensitizers, which help improve glucose uptake. Method: This research employsa laboratory experimental design using female rats as subjects. The rats were dividedinto three groups (n=10): normal rats, PCOS-IR rats (received an intraperitonealinjection of testosterone at a dose of 1 mg/100 g BW for 21 days), and PCOS-IR ratswith Moringa oleifera (received the same testosterone injection for 21 days followedby an administration of 500mg/kg Moringa oleiferaleaves extract for an additional 21days).Blood samples are subsequently collected and analyzed for HbA1c, and thegathered data will undergo statistical processing. Results: The PCOS-IR groupexhibited higher HbA1c levels than the negative control group, while the group treatedwith Moringa oleifera demonstrated significantly lower HbA1c levels than the PCOSIR group. The HbA1c levels in the Moringa oleifera treated group approached those ofthe control group. Conclusion: This research indicates that the 96% ethanol extract ofmoringa leaves may provide an effective alternative treatment for managing metabolicissues associated with PCOS-IR, particularly in relation to HbA1c levels