Indicators of transparency and data sharing in scientific writing in published randomized controlled trials in orthodontic journals between 2019 and 2023: an empirical study

Aim To identify data sharing practices of authors of randomized-controlled trials (RCTs) in indexed orthodontic journals and explore associations between published reports and several publication characteristics. Materials and methods RCTs from indexed orthodontic journals in major databases, namely PubMed® (Medline), Scopus®, EMBASE®, and Web of Science™, were included from January 2019 to December 2023. Data extraction was conducted for outcome and predictor variables such as data and statistical code sharing practices reported, protocol registration, funding sources, and other publication characteristics, including the year of publication, journal ranking, the origin of authorship, number of authors, design of the RCT, and outcome-related variables (e.g. efficacy/safety). Statistical analyses included descriptive statistics, cross-tabulations, and univariable and multivariable logistic regression. Results A total of 318 RCTs were included. Statement for intention of the authors to provide their data upon request was recorded in 51 of 318 RCTs (16.0%), while 6 of 318 (1.9%) openly provided their data in repositories. No RCT provided any code or script for statistical analysis. A significant association was found between data sharing practices and the year of publication, with increasing odds for data sharing by 1.56 times across the years (odds ratio [OR]: 1.56; 95% confidence interval [CI]: 1.22, 2.01; P < .001). RCTs reporting on safety outcomes presented 62% lower odds for including positive data sharing statements compared to efficacy outcomes (OR: 0.38; 95% CI: 0.17, 0.88). There was evidence that funded RCTs were more likely to report on data sharing compared to non-funded (P = .02). Conclusions Albeit progress has been made towards credibility and transparency in the presentation of findings from RCTs in orthodontics, less than 20% of published orthodontic trials include a positive data sharing statement while less than 2% openly provide their data with publication.