Research progress of hydrogen sulfide in acute kidney injury

Acute kidney injury is becoming a common and increasingly frequent disease. It is caused by a variety of factors， including ischemia reperfusion， nephrotoxic drugs and sepsis， eventually progresses to chronic kidney disease and end-stage kidney disease. Hydrogen sulfide （H2S） is the third endogenous gas signaling molecule secondary to nitric oxide and carbon monoxide that can be synthesized in almost all organs， including the kidney. Although research on the regulation of H2S in kidney physiology and pathophysiology is in its infancy， there is evidence that H2S production by kidney cells is reduced in disease states and H2S donors can ameliorate kidney damage. Specifically， abnormal H2S levels have been associated with a variety of renal pathological conditions， including acute kidney injury. This article reviewed the role and research progress of H2S in acute kidney injury， and discussed the prospect and challenge of H2S in the treatment of kidney disease， providing new ideas for clinical application of H2S.