Analysis of the efficacy of tranexamic acid combined with Q-switched laser and chemical peeling for the treatment of stable melasma

[Objective] To analyze the efficacy of tranexamic acid (TXA) combined with Q-switched laser and chemical peeling (α hydroxyl acid) for the treatment of stable melasma. [Methods] A total of 93 patients with stable melasma were recruited and randomly divided into group A (oral TXA+ chemical peels) with 31 cases, group B (oral TXA+Q-switched laser) with 32 cases, and group C (oral TXA+Q-switched laser+chemical peeling) with 30 cases. After the treatment, the efficacy was evaluated, and adverse reactions were observed. [Results] After 12-week treatment, the total effective rate in group C (80.00%) was significantly higher than that in group A (29.03%) and group B (56.25%) (both P<0.05 vs. group C). Skin lesion color, lesion area, and mMASI scores were lower in group C compared to groups A and B (both P<0.05 vs. group C). No severe adverse reactions occurred in any patients during the treatment. [Conclusion] The combination of tranexamic acid, Q-switched laser, and chemical peeling is an effective treatment for stable melasma, with few adverse reactions.