The mechanism of lenvatinib resistance in HCC

To investigate the mechanisms of lenvatinib resistance, we developed two lenvatinib-resistant cell lines, i.e., PLC/PRF/5-R (PLC-R) and MHCC97H-R (97H-R). We conducted comprehensive transcriptome sequencing analyses of lenvatinib-resistant cell lines (PLC-R and PLC-R) and patient tissues to identify critical genes and proteins associated with lenvatinib resistance. Then we chose MASTL for our further investigations.

Publication Details

Journal
China National GeneBank DataBase
Published
2025-01-01
DOI
https://doi.org/10.26036/cnp0007589
Primary Topic
Chronic Myeloid Leukemia Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

The mechanism of lenvatinib resistance in HCC

China National GeneBank DataBase
Chronic Myeloid Leukemia Treatments
article

The mechanism of lenvatinib resistance in HCC

article en

Abstract

To investigate the mechanisms of lenvatinib resistance, we developed two lenvatinib-resistant cell lines, i.e., PLC/PRF/5-R (PLC-R) and MHCC97H-R (97H-R). We conducted comprehensive transcriptome sequencing analyses of lenvatinib-resistant cell lines (PLC-R and PLC-R) and patient tissues to identify critical genes and proteins associated with lenvatinib resistance. Then we chose MASTL for our further investigations.

China National GeneBank DataBase
Openalex Percentile: Top 34%
Chronic Myeloid Leukemia Treatments
DOIOpen Access PDFOpenAlex
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The mechanism of lenvatinib resistance in HCC · China National GeneBank DataBase (2025) | TGRS Research Map | TGRS