Genetic clearance of p21-positive senescent cells accelerates fracture healing

Objectives: Age-related bone loss is driven by a process called cellular senescence. We recently demonstrated the transient appearance of senescent cells during fracture healing. These cells within the callus upregulate hallmarks of senescence, including expression of Cdkn1a (p21) and Cdkn2a (p16), [for full text, please go to the a.m. URL]

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Publication Details

Journal
German Medical Science (German Research Foundation)
Published
2024-10-21
DOI
https://doi.org/10.3205/24dkou493
Primary Topic
Telomeres, Telomerase, and Senescence
Type
article
Field-Weighted Citation Impact
0.00
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article

Genetic clearance of p21-positive senescent cells accelerates fracture healing

German Medical Science (German Research Foundation)
Telomeres, Telomerase, and Senescence
article

Genetic clearance of p21-positive senescent cells accelerates fracture healing

article en

Abstract

Objectives: Age-related bone loss is driven by a process called cellular senescence. We recently demonstrated the transient appearance of senescent cells during fracture healing. These cells within the callus upregulate hallmarks of senescence, including expression of Cdkn1a (p21) and Cdkn2a (p16), [for full text, please go to the a.m. URL]

German Medical Science (German Research Foundation)
Mayo Clinic (US), BG Klinik Tübingen (DE), Mayo Clinic in Arizona (US), Mayo Clinic in Florida (US)
Zero hunger
Openalex Percentile: Top 50%
Telomeres, Telomerase, and Senescence
DOIOpen Access PDFOpenAlex
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Genetic clearance of p21-positive senescent cells accelerates fracture healing · German Medical Science (German Research Foundation) (2024) | TGRS Research Map | TGRS