GC-MS analysis of cholesterol lowering dietary supplements

Controlling cholesterol levels and reducing the risk of cardiovascular disease requires the development of effective therapeutic strategies. In recent decades, dietary supplements (DSs) have gained attention as potential additions to conventional cholesterol management therapies, but their efficacy and safety are questionable. Accurate methods are required to evaluate the efficacy and safety of DSs. In the current study gas chromatography mass spectrometry was performed to analyze ten cholesterol-reducing DSs. The results showed that monacolin K/lovastatin was present in four samples. Moreover, using effective doses generally has minimal risks and lower incidence of adverse reactions and drug interactions. However, it must be taken into account the potential interaction of statins to induce myopathy and rhabdomyolizis. In order to prevent adverse effects, it is necessary to thoroughly evaluate and be careful when using DSs containing monacolin K.