Single-cell RNA sequencing dataset of hearts from wild type and Cyp26b1 knockout mouse embryos

LVNC (Left Ventricular Non-Compaction), which is a type of cardiomyopathy characterized by an abnormal heart muscle structure. Retinoic acid is crucial for normal heart development, including the regulation of myocardial differentiation and chamber formation. Cyp26b1 (Cytochrome P450 Family 26 Subfamily B Member 1) plays a key role in regulating retinoic acid (RA) signaling by degrading retinoic acid. However, more targeted research is needed to directly link Cyp26b1 with LVNC pathology specifically. To explore the transcriptional changes associated with Cyp26b1 deletion in heart development, we collected heart tissues from wild type and Cyp26b1 knockout mice at E10.5-E13.5 and performed single-cell RNA sequencing. Collectively, these data offer a valuable resource for researchers investigating the role of Cyp26b1 in heart development.