Ligand-Conjugates Targeting an Intracellular Allosteric Site for Neurotensin Receptor-1

Neurotensin receptor-1 (NTSR1) plays a crucial role in cellular signaling and has been implicated in various diseases, including cancer and neurological disorders. This thesis explores innovative strategies for targeting NTSR1 through the design of specialized ligands and conjugates. Key efforts include the development of bivalent ligands to investigate receptor interactions, fluorescent probes for advanced ligand screening, and therapeutic conjugates designed to exploit receptor-specific mechanisms. These approaches aim to enhance our understanding of NTSR1 function and provide novel tools for its potential therapeutic targeting. The findings contribute to broader efforts in drug discovery and receptor biology.